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238 The high concentration of insulin in the local pancreatic environment creates a negative feedback effect, reducing the amount of glucagon secreted by -cells

In other words, one of the highest-selling new drugs has become a GLP-1 therapy

The Wnt Signaling Pathway Effector TCF7L2 Controls Gut and Brain Proglucagon Gene Expression and Glucose Homeostasis

There's little evidence that GLP-1 patches work at all, let alone better than clinically approved weight loss injections

433 Specifically, alcohol-dependent rats were administered semaglutide, which resulted in a significant reduction in their alcohol consumption

Which almost never happens, especially in a journal as prestigious as PNAS (Delaye