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Hunger returns because the appetite-suppressing effect is absent The satiety hormone GLP-1 is released back at its original level Due to previously reduced body weight, the basal metabolic rate may have decreased If dietary and exercise habits have not been permanently adjusted, the weight increases again Brajan Budini and Steven Luo from the University of Cambridge evaluated six randomized controlled trials with a total of over 3,200 patients

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Consequently, modulation of the reward system represents an additional mechanism by which GLP-1 analogs may be beneficial in treating specific EDs, such as BED

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