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Tocilizumab is beneficial for CRS but may exacerbate immune effector cell-associated neurotoxicity syndrome (ICANS) due to inadequate central nervous system penetration, whereas corticosteroids are favored for ICANS despite apprehensions over their potential to diminish CAR T-cell efficiency

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For example, approved cardiac glycoside drugs such as digitoxin, digoxin, and ouabain have been shown to be competitive inhibitors of spike:ACE2 binding 29

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