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A 2024 pooled analysis of the SURMOUNT trials (Aronne et al., Lancet ) found that 4.3% of patients discontinued tirzepatide due to GI side effects

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Patients undergoing GLP-1 RA therapy who adopt unstructured reductions in dietary intake should be closely monitored for gut microbiome dysbiosis, as preservation of gut microbiome eubiosis is foundational to health