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In the early to mid-1990s, investigators reported the expression of IGF-1 in the PZ of the epiphyseal growth plate measured by in situ hybridization [87,200,201], and these findings were replicated in a separate study a decade later [31]

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And so far, research raises serious concerns

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All three share similar gastrointestinal side effect profiles: nausea, diarrhea, constipation, and abdominal discomfort