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This reminds me Toni Vidal-Puig MD PhD FRCP FMedSci MAE MBA comment about organ vulnerability: obesity may be heterogeneous in terms of which organ becomes the first weak link in the chain of events that form vicious cycles

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On one hand, 1,25(OH)D can attenuate VDR ubiquitination and delay its degradation (17)

10.1002/bmb.2005.494033032451 17 BalesB