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FGF21 is produced primarily in the liver in response to metabolic stress and acts as a systemic regulator of energy balance stimulating fatty acid oxidation, promoting adiponectin secretion, and supporting healthy mitochondrial function in brown adipose tissue.* FGF21 levels are closely correlated with metabolic flexibility the ability of cells to switch efficiently between fuel sources

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Sikiric is named on BPC-157-related patent applications dating back to at least 1989, and Croatian government records list Predrag Sikiric as an owner of PharmaCotherapia, the company that sponsored the Tijuana trial