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The inhibitory pathway consists of vagal preganglionic neurones releasing ACh, connecting to postganglionic neurones that release nitric oxide (NO), vasoactive intestinal peptide (VIP), adenosine triphosphate (ATP) and substance P (SP)

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(You may also see the newer terms metabolic dysfunction-associated steatotic liver disease (MASLD) and metabolic dysfunction-associated steatohepatitis (MASH) used alongside NAFLD and NASH in recent guidance.) NAFLD is strongly associated with metabolic syndrome, encompassing conditions such as obesity, type 2 diabetes, hypertension, and dyslipidaemia