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Fat loss is not selective, when the body sheds fat, it draws from facial fat pads as well as body stores
Dropping the 1mg arm acknowledges that while it produced statistically significant weight loss, the magnitude was insufficient for a competitive regulatory filing
Professional society guidelines incorporate GLP-1s for patients with diabetes and high CVD risk
doi: 10.1056/NEJMoa1509225
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The mechanism is not fully understood, but inflammation, abnormality of the guts mechanoreceptors and emotional states such as hypervigilance and stress likely play a role (39)
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