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Medicare spending on GLP-1s has surged, raising concerns about long-term affordability and access 2
10.1172/jci75276 111 SharmaD.VermaS.VaidyaS.KaliaK.TiwariV
25 however, emerging evidence supports the notion that intestinal SMCs are affected functionally and structurally by most inflammatory conditions involving the intestine leading to altered morphology and contractile behavior, and secretion of various inflammatory mediators
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Beyond necessitating higher doses and increasing patient burden, low bioavailability raises the risk of the hook effect, where excessive concentrations promote the formation of non-productive binary complexes over functional tertiary complexes, thereby diminishing degradation efficiency
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