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Primary and Secondary Endpoints The primary endpoint was the percentage change in body weight from baseline to 72 weeks

For the wider picture, the GNL guide on overcoming insulin resistance in T1D sits alongside this conversation

GLP-1RAAssociated diabetic lumbosacral radiculoplexus and common fibular neuropathies: A Case-Control evaluation

This is usually achieved through a consistent weight loss over time, with common results being around a 6% weight loss after three months, 11% after six months, and higher percentages as patients move beyond a year of treatment

5.9 Hyperammonemia Hyperammonemia has been reported in association with valproate therapy and may be present despite normal liver function tests

The calories in versus calories out approach to weight loss doesnt always paint the whole picture