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In the BLOOM trial, patients treated with lorcaserin achieved highly significant and absolute weight loss in 1 year, and continuous treatment with lorcaserin over 2 years helped two-thirds of the patients maintain a weight loss of 5% or greater [83]

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It also preserved activities of mitochondrial enzymes and prevented the drop in synaptic protein expression that was seen in controls

Angiogenesis (2014) 17(3):47194