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HCV genotypes, subtypes and anti-HCV therapy As mentioned previously, HCV strains are classified into seven genotypes based on the phylogenetic and sequence analyses of HCV genomes, and within each genotype, HCV is further classified into 67 subtypes46

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By using rapid membrane emulsification solvent evaporation method, the drug was encapsulated in nanoparticles, significantly improving the in vitro dissolution rate: in acetic acid sodium acetate buffer containing 0.1% SDS (pH 3.6), the cumulative release rate reached 94.0% after 4 hours, while the active pharmaceutical ingredient was only 54.6%