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Osteoarthritis: Particularly in weight-bearing joints like knees and hips, osteoarthritis is exacerbated by excess weight

The specific blockade of somatostatin receptor 2 (SSTR2) resulted in a notable increase in glucagon secretion, effectively reversing the inhibitory effect of GLP-1 [48, 49]

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Central appetite regulation The medication influences appetite centres in the brain to reduce hunger signals and increase satiety signals Enhanced post-meal satisfaction Patients typically report feeling satisfied with smaller portion sizes Clinical trials have demonstrated that patients taking semaglutide experience reductions in appetite and caloric intake