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The STEP 1 extension study showed approximately two-thirds of weight was regained within one year of stopping semaglutide

A 2026 Oxford University study found patients regained an average of 0.8 kg (about 1.7 lbs) per month after stopping

On and off the court

The exact mechanism of weight loss for both combinations is still unclear, but there are several hypotheses

"In fact, the big studies coming out are telling us that [after taking one of these medications] for about a year to a year-and-a-half, people are achieving about 15% to 20% weight loss." Additionally, patients are seeing improved liver function and lower rates of stroke as well as kidney and heart disease