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& Higashino, K

10.1111/j.1460-9568.2005.04426.x 81

Mahan, J.L

Experimental studies suggest that inhibition of NNMT may increase intracellular nicotinamide availability, thereby supporting NAD biosynthesis and improving mitochondrial oxidative metabolism

86 Some evidence suggests individuals with MTHFR polymorphisms may need higher doses of folic acid to experience therapeutic benefits and may respond better to supplementation with 5-methyltetrahydrofolate (5-MTHF), the active form of this B vitamin