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In contrast, curcumin has demonstrated coordinated inhibition of DNMTs (DNMT1, DNMT3A, DNMT3B), suppression of histone deacetylases (HDAC1, HDAC3), and modulation of non-coding RNAs and m 6 A RNA methylation within the same cellular context
Intracellular ROS and/or RNS induced the production of protein hypersulfonic acid (P-SOH) or glutathione hypersulfonic acid (GSOH) intermediates, leading to modification
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Unlike GLP-1RAs, particularly dulaglutide (254), SGLT-2 inhibitors have not demonstrated cardiovascular benefits in primary prevention among individuals with multiple cardiovascular risk factors (261)
(PubMed) (PubMed) Miller JW, Rucker RB
