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A gene modulator is a molecule that can interact with this system to restore a more favorable pattern of expression

Navrot et al

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In turn, these free radicals cause further mitochondrial damage and so create a vicious cycle of less energy and more damage

This also raises the question whether PARP activity in BRCA1/2-deficient tumors produces a similar metabolic phenotype via NAD + depletion and whether the use of a PARP inhibitor (e.g., olaparib) to treat these tumors 10 might restore NAD + levels and counterbalance GAPDH inhibition by other oxidative agents