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The article attributes it to several mechanisms at once: increased metabolism, gastrointestinal side effects that disrupt nocturnal comfort, and potential central nervous system effects

As effort climbs or duration extends past three hours, most athletes transition to gels which require less digestive effort

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In comparison, the other region of GSH contains three hydrogen bonds and several hydrophobic interactions with OsDHAR as well as strong electron density

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doi: 10.1111/dom.12932, 9 BoothM