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Pulmonary administration via dry powder inhaler circumvents first-pass effects and diminishes enzymatic degradation reactions (Newman, 2017)

However, one limitation of using mitochondrial dysfunction as a diagnostic biomarker for ME/CFS is that other diseases such as fibromyalgia [56, 102], metabolic syndrome, cardiovascular diseases, cancer [103] and neurological disorders (such as Parkinsons [104] and Alzheimers disease [105,106,107]) are also associated with mitochondrial dysfunction

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