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These markers encompass a range of biochemical abnormalities, such as altered ratios of mtDNA to nuclear DNA, and aberrant expression of mitochondrial inner membrane and matrix proteins [81,90]

Further works are needed to translate research on iPSCs and ESCs into actual therapies for DKD

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1/Smad2/3 axis, a key pathway in fibrosis and epithelial-mesenchymal transition, thus reducing tissue fibrosis and promoting regenerative over fibrotic repair 4