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On published endpoints, Novo Nordisk's April 2024 Phase 3 readout in type 2 diabetes reported a 14.2% mean body-weight reduction at 68 weeks for CagriSema 2.4mg/2.4mg from a 101kg baseline, versus 10.2% for semaglutide 2.4mg alone [4]

(eds) Mushroom Bioactives: Bridging Food, Biotechnology, and Nanotechnology for Health and Innovation

PubMed Web Address Barends, T., White, T

Understanding this trajectory helps explain why early intervention matters and how Retatrutide can alter the course

Nonetheless, the magnitude of weight reduction observed at higher doses is notable given that achieving substantial weight loss in individuals with type 2 diabetes has historically been more difficult than in those with obesity alone, partly due to the metabolic effects of the condition itself and certain antidiabetic medications

All dosages available, including higher doses unavailable in Ireland