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Two active forms of GLP-1 are generated in the gut and brain: active GLP-1 (7-36) amide and active GLP-1 (7-37) non-amide 10
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Improved glycaemic control with minimal hypoglycaemia and no weight change with the once-daily human glucagon-like peptide-1 analogue liraglutide as add-on to sulphonylurea in Japanese patients with type 2 diabetes
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Severity and duration matter as much as incidence
The researchers found that while semaglutide did not alter insulin sensitivity, as measured by pAkt:Akt ratio, it did significantly increase the expression of genes associated with mitochondrial biogenesis and function, including PGC-1, and TFAM
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