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Gut Microbes [Internet] Gut Microbes

4.4 Interactions between cartilage and synovium 4.4.1 Interplay between cytokines released by chondrocytes and synovial cells When cartilage is damaged, chondrocytes release proteoglycan fragments, type II collagen fragments, and diverse injury-associated factors that synovial cell surface pattern recognition receptors (PRRs) can detect, prompting synovial hyperplasia and proinflammatory cytokine secretion (139)

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Integrin 1 signaling is necessary for transforming growth factor- activation of p38MAPK and epithelial plasticity

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It can be found also in saliva and urine