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10.1002/cncr.25414 67 GanZ.WeiW.WuJ.ZhaoY.ZhangL.WangT.et al (2019)

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Compared with NRAS activating mutations at positions 12 and 13, NRAS Q61 mutations exert a stronger activating effect on the MAPK pathway since codon 61 is the catalytic residue for GTP hydrolysis and Q61 mutation impedes the return of RAS to an inactive GDP-bound state (92)