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Data Availability Statement No datasets were generated or analysed during the current study.

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In absence of modification on the downstream signaling pathway, G protein uncoupling is a good marker for desensitization but can't be applied for G protein-independent pathways (i.e., MAP kinases)

(15) quantitated -tocopherol absorption in healthy women using two different forms of deuterium-labelled -tocopherol

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If you notice reduced effectiveness at doses that previously worked well, degradation is a likely culprit