The best control of HbA1c levels was reached within 18 weeks (mean change: 1.10 0.61%), and when the follow-up was from 18 to 52 weeks, the decrease in HbA1c was slightly lower but remained stable
(PDF) Abbreviations 5,10-methyleneTHF: 5,10-methylenetetrahydrofolate THF: tetrahydrofolate DHF: dihydrofolate dUMP: deoxyuridine monophosphate dTMP: deoxythymine monophosphate 5-methylTHF: 5-methyltetrahydrofolate cSHMT: cytosolic serinehydroxymethyl transferase mSHMT: mitochondrial serinehydroxymethyl transferase MTHFR: methylenetetrahydrofolate reductase TYMS: thymidylate synthase DHFR: dihydrofolate reductase Declarations Conflict of interest The authors have no conflict of interests related to this publication
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long-term use can cause significant adverse effects including kidney problems, hypertension, and non-melanoma skin cancers (Paul 2003