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While retatrutide and SAR441255 demonstrate significant potential, several important aspects must be addressed to fully optimize the clinical application of triple agonists
doi:10.3390/pharmaceutics17121596 15
New England Journal of Medicine , 384 (11), 9891002
In rodent models, liraglutide stimulates calcitonin release and causes C-cell hyperplasia and tumor formation (51)
Reduced motility allows bile to stagnate, which promotes cholesterol crystal formation and gallstone development
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