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agents targeting these channels provide analgesia

doi: 10.1073/pnas.87.12.4879 210

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In mice with lipopolysaccharide (LPS)-triggered acute respiratory distress syndrome, mitogen-activated protein kinase (MAPK) and nuclear factor kappa-B (NF-B) signaling are activated, leading to up-regulation of matrix metalloproteinase-9 (MMP-9) and a reduction in SDC-1, indicating glycocalyx destruction