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10c,d) and reduced AMPK expression (Extended Data Fig

In a second assay, we investigated whether SOS-catalyzed nucleotide exchange to a non-hydrolyzable GTP analog (guanosine-5-[( , )-imido]triphosphate, GppNHp) and effector binding were still possible after covalent modification with the ligand

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One of the physiological changes seen is the tempering of the bodys most powerful antioxidant: reduced glutathione

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