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10.1182/blood.2020006104 67

Abstract The pathophysiology of ALS involves many signs of a disruption in copper homeostasis, with both excess free levels and functional deficiency likely occurring simultaneously

Inhibition of D1 and D2 due to inflammation is the most common cause of low T3 but D3 is also a contributing factor to low T3 and increased rT3

[38] [39] [40] After administration, selegiline partially metabolizes into levomethamphetamine and levoamphetamine, which act as norepinephrine releasing agents (NRAs) and may contribute to its therapeutic and adverse effects as well

Whether vaginal or Caesarean delivery is better remains controversial

For non-topical routes of administration, safety data remain more limited and require further investigation