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In SICLOPPS, split-intein domains, comprising separately expressed N-terminal (IN) and C-terminal (IC) segments of an intein, reassemble within cells to form an active intein (Scheme )

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Based on current evidence, inhaled GSH cannot be recommended for emphysema/COPD or asthma, the latter of which exhibited notable side effects (e.g., breathlessness, bronchoconstriction, cough), most likely due to co-occurrence of asthma and sulfite sensitivity

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