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Most of the studies have shown its therapeutic role in melasma, whereas some studies have contradicted this fact[] [Table 1]

Our results indicate that in hDAT cells, AA, under both oxidative and non-oxidative conditions, decreases significantly and to the same extent plasma membrane DAT (Figures 4a and b) as determined by biotinylation

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The two forms serve different mechanisms, and combining them adds complexity without clear evidence of additive benefit

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