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Higher testosterone relative to estrogen reduces stimulation of breast tissue

Canganella F, Paganini S, Ovidi M, Vettraino AM, Bevilacqua L, Massa S, Trovatelli LD (1997) A microbiology investigation on probiotic pharmaceutical products used for human health

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63 Together, these findings indicate that (i) the sensitivity of tumors to insulin and IGF-1 parallels their response to CR, and (ii) neither the activation status of PI3KAKT per se nor mutation status of individual genes predicts for the sensitivity of tumors to both growth factors and CR