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Research indicates FOXO4-DRI treatment does not compromise the chondrogenic capacity of retained cells, though additional interventions may enhance cartilage matrix production following senescent cell clearance

Disruptions in these molecular interactions, whether due to genetic factors, biochemical imbalances, or hormonal influences, can compromise the ligaments ability to withstand stress

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However, in the context of dysbiosis, this immune response is often exaggerated and prolonged, leading to chronic inflammation as reported [44]

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