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International journal of cosmetic science , 27 (5), 271278

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Metformin reduces gluconeogenesis by acting on the liver as well as adipose tissue, skeletal muscle, endothelium, and the ovaries [124]

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It is also worth noting that cardiovascular risk in a HIV patient is higher than in a patient without HIV (by up to 60% and more), and antiretroviral agents, in particular protease inhibitors, increase the risk as much as two-fold [392, 393]