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Moving beyond symptomatic management, targeting the core drivers of this pathological cycle holds promise for modifying disease progression

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Ferroptosis in diabetes Since iron plays a key role in metabolic disease processes (such as glucose oxidation) and metabolic regulation (such as hypoxia sensing), it is involved in determining key energy metabolic links such as metabolic rate, gluconeogenesis, fuel selection, and insulin action

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Through direct gene repression and indirect regulation through microRNAs, BRD4 and HMGA1 influence how chromatin dynamics intricately govern autophagic homeostasis across disease contexts

Mutations in ferroportin resulted in Mn accumulation and cytotoxicity in vitro ( Overall, ZIP14, ZIP8, DMT1, and ZNT10 appear to mediate the majority of Mn transport, supported by extensive in vitro and in vivo evidence, with other pathways contributing to a lesser extent