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Persistent inflammatory factors stimulate HSCs in the liver to secrete fibrotic factors that increase extracellular matrix (ECM) formation and ultimately lead to liver fibrosis (Eraky et al., 2018)

Craig Koniver notes that they are observing good results with pentadeca arginate, including reduced inflammation, making it a promising alternative to BPC 157 1

MMA rises when there is not enough B12 in the mitochondria (the cells energy factories) to process fats and proteins so that they can be burnt as fuel for energy

Heme oxygenase (HO), a major cytoprotective enzyme, functions upstream of Wnt signaling and lowers lipogenesis and adipogenesis, decreasing lipid accumulation and levels of proinflammatory cytokines [99]

doi: 10.1038/s41590-019-0378-1 60 StephensonWDonlinLTButlerARozoCBrackenBRashidfarrokhiAet al

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