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It is crucial to remember that this formulation should not be applied to broken or irritated skin

However, as we stated in the proposed rule, we have come to understand that if hospitals use substantially different lookback periods, particularly across multiple years, it could distort the allowed amounts, for example, because of pricing changes over time such as inflation, efficiencies, or the introduction of new products or services

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Vendor-assigned expiry dates (commonly 1224 months for lyophilised material) are based on internal validation rather than peer-reviewed stability studies [12][unverified]

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