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This enzymatic action depletes the available intracellular pool of nicotinamide, directly limiting the synthesis of nicotinamide adenine dinucleotide (NAD+)

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The KEGG pathway also predicted the FOXO signaling pathway (hsa04068) with an FDR of 1.41E-07, indicating probable significance, which could have resulted in more false results

4B and Additional file 1: Fig

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doi:10.7759/cureus.12360Google ScholarPubMed Golubchik, P, Sever, J, Weizman, A