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Researchers have reported that for healthy individuals, supplements with high doses of vitamin b12 (1000-2000 mcg daily) may be as effective as intramuscular shots for people who are deficient.(14) Beyond the Brain: Additional reasons to take B12 Cardiovascular System : Especially in combination with other B vitamins, it helps lower homocysteine levels

2024 May 2;

Fishman EK, Soyer P, Bliss DF, Bluemke DA, Devine N

Whilst some studies found beneficial effects in patients with AD 36 and dementia 90 and in shift workers, 91 others found no improvements in patients with sleepwake rhythm disorders