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Promotes Beta Cell Health: GLP-1 supports the health and function of pancreatic beta cells, which produce insulin

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In Phase 2 and Phase 3 clinical trials, retatrutide has been investigated as a once-weekly subcutaneous injection

Safety Profile, Side Effects, and Guidance The most common side effects are gastrointestinal, including nausea, vomiting, and diarrhoea

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Other studies using rodents or primates with immunofluorescent reporter GLP-1Rs verify the expression of GLP-1Rs by pyramidal (glutamergic), GABAergic and catecholaminergic neurons in feeding, energy homeostasis, fear, stress, motivation/reward, learning plus memory as well as Alzheimers disease (AD) and Parkinsons Disease (PD)-associated key brain areas, such as the hippocampus, hypothalamus, cortex, striatum, amygdala, SNpc, or ventral tegmental area (VTA) (Cork et al., 2015