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Studies have shown that 1,25(OH)D directly suppresses renin gene transcription in juxtaglomerular cells, thereby reducing angiotensin II levels and mitigating RAAS overactivation (39)

(1) Z Abdel-Malek, V B Swope, I Suzuki, C Akcali, et al (1995) Mitogenic and melanogenic stimulation of normal human melanocytes by melanotropic peptides

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Samples of culture supernatant quenched by addition of formic acid to a final concentration of 0.1% were analyzed by LC-MS/MS to quantify concentrations of d 9 -TMA, d 9 -l-carnitine, and/or d 9 -BB

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Although the list of prohibited substances and methods is updated at least annually, its open-ended nature continues to pose challenges in definitively determining the status of many substances found in dietary supplements or medications, which may lead to unintentional violations of anti-doping rules