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Medical conditions: Both medications can be used for weight management in adults with obesity or overweight and at least one weight-related condition (such as type 2 diabetes, high blood pressure, or high cholesterol)

Glomerular pressure Glomerular hypertension increases the physical stress on the glomerular capillaries, while the glomerular filtration of tubulo-toxic factors (e.g., albumin, growth hormones, advance glycation end products) that accelerate glomerulosclerosis reduces nephron numbers and induces renal dysfunction [6, 7]

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The prevalence of fasting serum glucose 5.6 mmol/L (100 mg/dL) or HbA1c 38.8 mmol/mol (5.7%) reduced from 100% at baseline to 5587% with tirzepatide versus 8799% with comparators at Week 40/52

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Once we have the tools to fight it and treat patients, hopefully the stigma towards obesity goes down