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When the same spot gets used repeatedly, fatty tissue can thicken and form lumps (lipohypertrophy), which makes future injections uncomfortable and can reduce how effectively your medication is absorbed

The 2mg starting dose was well tolerated in the trial, with gastrointestinal effects -- nausea, diarrhea -- most common at higher doses

475 Based on data from the Chicago Health and Aging Project, in 2020 an estimated 700,000 people age 65 and older in the United States had Alzheimer's dementia at death

10.1038/s42255-020-0238-1 66 LeveyA