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Higher activity of antiapoptotic proteins, enzymes and signaling cascades has been observed in mania, which enhances mitochondrial activity (76)

In a phase 1, randomized, double-blind, placebo-controlled clinical study in participants with obesity (NCT04478708), AMG 133 had an acceptable safety and tolerability profile along with pronounced dose-dependent weight loss

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Further mechanistic studies are needed to test these hypotheses and explore potential mechanisms of action of GIP analogues, such as Tirzepatide tested here, for reducing alcohol intake