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The FDAs decision was supported by data from the Phase II ROSEWOOD trial, in which the BrukinsaGazyva combo led to a 69% overall response rate (ORR) compared to 46% ORR in patients treated with Gazyva alone, according to BeiGene

Furthermore, the study of the non-transport-related functions of junctional proteins should yield promising insights into cancer pathogenesis, immune function, and identifying biomarkers [88]

The underlying mechanism is linked to heightened oxidative stress, as indicated by elevated levels of ROS and MDA, alongside decreased concentrations of SOD and GPx in the brain

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