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However, evidence from research studies suggests that GLP-1 analogs may also reduce gastric acid secretion, which can impair the conversion of dietary B12 into its absorbable form and decrease binding to intrinsic factor, both of which are necessary for proper absorption

Before pursuing B12 injections or other interventions marketed for weight loss, patients should consult their GP for proper assessment, investigation of any underlying medical conditions affecting weight, and discussion of evidence-based treatment options

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[2] For this reason, elevated serum homocysteine over 15 micromol/L and methylmalonic acid (MMA) over 0.271 micromol/L are considered better indicators of B 12 deficiency, rather than relying only on the concentration of B 12 in blood

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Whilst extremely rare, anaphylaxis to B12 preparations has been documented