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Carnitine acetyltransferase (CrAT) can act as safety valve to catalyze the reversible transfer of acetyl groups between acetyl-CoA and acetylcarnitine, promoting the combination of excess acyl groups with carnitine, increasing the membrane permeability of these products and thus removing them from the mitochondria, allowing acylcarnitine to be formed in the mitochondrial matrix and exported to the plasma [7]

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Amyotrophic lateral sclerosis Amyotrophic lateral sclerosis (ALS) is an adult-onset neurodegenerative disorder in which spinal and cortical motor neurons progressively degenerate

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