Tirzepatide is a medication that activates both GIP and GLP-1 receptors to enhance insulin secretion, reduce appetite, and slow gastric emptying, leading to significant weight loss and improved blood sugar control
It is a carotenoid derivative, which produced in the liver and results from the breakdown of -carotene
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Data Last Updated 12/01/2025
In the present study, we used only male mice to minimize variability introduced by the estrous cycle in females, which is known to influence toxicity, body weight, food intake, and metabolic parameters [31,32,33,34,35,36]
It is advised to use GLP-1 RA for individuals with type 2 diabetes, symptomatic heart failure with preserved ejection fraction, and obesity, as it has shown significant benefits